That may not sound like much, but in a quiet field where most people go through their entire careers without discovering a marketable drug, it’s tough to make a name for yourself. Derek Lowe is perhaps America’s best-known medicinal chemist. You want good data or you want fast data, and we've been getting fast data mostly up until now with all the problems that come with it. These are the ones given to cattle, not the ones athletes give to themselves. I later moved to North Carolina full-time and held four other positions starting as senior research pharmacologist at Research Triangle Institute (RTI International, 2002-2008) and professor and chair of the Department of Pharmaceutical Sciences at North Carolina Central University (2008-2011), a historically black college/university (HBCU) in the University of North Carolina system. Derek Lowe: You get to choose. After receiving his PhD in chemistry from Duke University, he was awarded a Humboldt fellowship to do postdoctoral research in Germany. The blog has forced me to keep up with the scientific literature, both in drug discovery and associated areas. After a postdoctoral fellowship in medical oncology and molecular endocrinology at the University of Colorado School of Medicine (1990-1992), I joined the faculty of Colorado's School of Pharmacy in the Department of Pharmaceutical Sciences. Their letter seems to argue that his Utah blog post was defamatory. 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Forbes Senior Editor Matthew Herper invited me to contribute here at Forbes beginning in October 2010. My cancer research laboratory focused on drug discovery from natural sources, such as plants, fungi and microorganisms, and the bioactivity of herbal medicines. Exclusive analysis of biotech, pharma, and the life sciences. A research chemist originally from Arkansas... Derek Lowe. It’s the same motley crowd as ever. I tell people: “If you want to know why your prescriptions cost so much, it’s me.” I’ve done nothing but spend money the entire time. Number Seven: Synthetic Growth Hormones. A Chemist's Guide to Vaccine Production and Bottlenecks By The Open Mind on PBS. Leave this field empty if you're human: Ask me anything about drug discovery, chemicals no one should work with, and more. The molecules that Lowe synthesizes may have made it into preclinical efficacy trials (i.e., animal models of the disease in question). That helped me scientifically, and of course, it’s given me a lot of visibility, which has been no harm, either. He’s worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer’s, diabetes, osteoporosis and other diseases. If I understand correctly, Lowe has worked almost exclusively on classical small-molecule therapeutics and not large biotech-derived protein therapeutics. Is this you? 23 talking about this. I've been interested in journalism and mass communication ever since writing as a music critic for my high school newspaper and this interest percolated under the duration of my professional scientific career. I report on all things. Derek Christopher Lowe (born June 1, 1973) is an American former Major League Baseball pitcher.During his career, he played for the Seattle Mariners, Boston Red Sox, Los Angeles Dodgers, Atlanta Braves, Cleveland Indians, New York Yankees, and Texas Rangers.. Lowe threw a no-hitter for the Red Sox in 2002. Derek Lowe is a chemist, researcher, and writer whose “In the Pipeline” blog has become a touchstone for many chemists and scientists each day. Failure is part of science. Karen Weintraub is an independent Lowe's site, now at Science Translational Medicine, has been the daily go-to for all manner of R&D scientists even peripherally associated with drug discovery and development. He replied, "I’ve seen people who couldn’t stand their ideas not working. He’s also considered one of the first science bloggers. Weintraub asked Lowe if he ever gets tired writing about failures in drug development. Anytime there's an important paper, company acquisition or merger, drug approval or drug tragedy, Lowe's clear, concise writing and erudite commenters bring clarity and perspective that truly can't be found anywhere else. But once in preclinical studies, the drug might turn out to have unexpected, off-target effects. You don't get a lot of credit for failures. 2. I’m leaving a huge pile of stuff on the Internet for free. Derek Lowe is perhaps America’s best-known medicinal chemist. are strictly my own – I don’t in any way speak for my employer (or anyone else). Derek Lowe Derek has degrees in chemistry from Hendrix College, and Duke, and has been working in the drug industry for over 30 years. I also taught various aspects of herbal and dietary supplements. Some medicinal chemists can’t get enough fluorines in their molecules. He’s worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer’s, diabetes, osteoporosis and other diseases. Early failures save energy and resources from being wasted. In fact, failure is necessary for science to progress. Archive is created by fans, for fans. Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry... [+] from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. But carefully constructed experiments that "fail" tell you something that allows the science to move forward. Derek Lowe's commentary on drug discovery and the pharma industry. Derek Lowe Director, Chemical Biology Therapeutics -Novartis ... Drug discovery chemist and blogger Note: all opinions, choices of topic, etc. I certainly understand Lowe's intent to show how much failure goes into drug development. But making chemical changes to minimize metabolism sometimes lowers or even eliminates the potency of the drug. In drug development, one of Lowe's "failures" might be key to keeping a dangerous drug from making it to market. Derek Lowe relishes a celebration of the lab on its long march through time. And I welcome commenters who might care to provide their own. Derek Lowe, on a career in pharma From a very interesting interview in Trends in Pharmaceutical Sciences, Derek Lowe speaks: What caught my eye this weekend was one of Lowe's quotes from the STAT article that got a bit of traction on social media: I’ve been doing this for 27 years, and I have never once put a drug into a pharmacy. HELPING CHEMISTS FIND JOBS IN A TOUGH MARKET. As an organic chemist, ... Derek Lowe's commentary on drug discovery and the pharma industry. I've been a graduate advisory board member and lecturer for the MS in Medical and Science Journalism Program at the University of North Carolina since 2004 and worked as a full-time science and medicine journalist from 2014 to 2018. Sign up for our morning rounds newsletter. 1. You may opt-out by. I've been writing science blogs since 2005: My Terra Sigillata drug information blog was hosted at ScienceBlogs and American Chemical Society CENtral Science, while Take As Directed was hosted at the PLOS network. When I make a compound no one else has ever made, even these days, I think, “There it is, never in the universe before, until I did it with my hands.” It’s ego partly, and it’s just sheer curiosity. I would love to leave a scientific legacy. If you can’t stand your ideas not working, you shouldn’t be in science.". This magnificent book lists 250 of the most intriguing and significant advances and events in chemistry, on a timeline starting in 500,000 BCE and running right past us to 2030, when the author, Derek Lowe, anticipates that someone will solve artificial photosynthesis. Drug discovery chemist and Science Magazine blogger Derek Lowe discusses COVID-19 … I report on all things pharmaceutical and scientific from Denver, Colorado, where I direct master's degree and certificate programs at the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences. Dr Lowe writes the blog, In The Pipeline . While he can never write about his proprietary projects where he works (at Vertex, but at several other companies previously), his 14 years of blog writing gives some insight as to the value of failure in drug development. Welcome to the official Facebook page of Derek Lowe! To me, those failures are major contributions. Derek Lowe: The chemist who puts a human face on drug development advertisement. He blogs at In the Pipeline. After that it wasn't long before Lowe tells us that he got a strongly-worded letter from a law firm, Snell & Wilmer. A trial in China should be underway by the time you read this, and one in the US is slated to start by the end of the year. The earlier you know this, the earlier funds and personnel can be directed toward more promising projects. Fluorine is a nasty element. Derek Lowe explains the love-hate relationship. Chemistry. Our work was supported by grants from the National Institutes of Health (NCI, NIGMS) and the American Cancer Society. 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It gives me more visibility, so the motley crowd grows larger. Since 1989, chemist Derek B. Lowe, has worked for several major pharmaceutical companies on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis, and other diseases. Derek Lowe (@Dereklowe) is a medicinal chemist working on preclinical drug discovery in the US. I was fortunate to receive 11 teaching awards, including election as a President's Teaching Scholar of the University of Colorado. author. Photo credit: Science Translational Medicine. I’ve been doing this for 27 years, and I have never once put a drug into a pharmacy. The molecules that Lowe synthesizes are essential to understanding how candidate drugs would be metabolized. Derek has 5 jobs listed on their profile. Season 11 player (1995-05-24). A medicinal chemist by training, the then-Pfizer scientist began his In the Pipeline blog at Corante way back in 2002–antiquity in blog years. 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